Assessing Ganglion Cell Layer Topography in Human Albinism Using Optical Coherence Tomography

Here, we used OCT to image the fovea and assess inner retinal layer excavation in human albinism, specifically through quantifying the topography of the GCL and IPL. Moreover, we have developed a repeatable method to measure the GCL and IPL independently, rather than the combined GCIPL that is commonly used. We show that these layers have greater structural variability than previously reported and that their topography differs significantly from that observed in control participants. We also discuss the significance of these findings for visual system development in albinism.